α-amine-ω-propionic acid tetraethylene glycol

α-amine-ω-propionic acid tetraethylene glycol - Names and Identifiers

Name	α-amine-ω-propionic acid tetraethylene glycol
Synonyms	Amino-PEG4-acid Amino-dPEGx-acid H2N-PEG4-CH2CH2COOH Α-AMINE-Ω-PROPIONIC ACID TETRAETHYLENE GLYCOL α-amine-ω-propionic acid tetraethylene glycol 1-AMino-3,6,9,12-tetraoxapentadecan-15-oic acid alpha-aMine-oMega-propionic acid tetraethylene glycol 3-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]propionic acid
CAS	663921-15-1
EINECS	828-940-4

α-amine-ω-propionic acid tetraethylene glycol - Physico-chemical Properties

Molecular Formula	C11H23NO6
Molar Mass	265.3
Density	1.134±0.06 g/cm3(Predicted)
Boling Point	409.6±40.0 °C(Predicted)
pKa	4.28±0.10(Predicted)
Storage Condition	2-8°C
Physical and Chemical Properties	Bioactive NH2-PEG4-CH2CH2COOH is a degradable (cleavable) 4-unit PEG-like ADC linker used in the synthesis of antibody-coupled drugs (ADCs). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
In vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

α-amine-ω-propionic acid tetraethylene glycol - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	3.769 ml	18.847 ml	37.693 ml
5 mM	0.754 ml	3.769 ml	7.539 ml
10 mM	0.377 ml	1.885 ml	3.769 ml
5 mM	0.075 ml	0.377 ml	0.754 ml

Last Update：2024-01-02 23:10:35

α-amine-ω-propionic acid tetraethylene glycol - Uses and synthesis methods

target

Cleavable

PEGs

in vitro study

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Last Update：2024-04-09 21:01:54

α-amine-ω-propionic acid tetraethylene glycol - Reference Information

biological activity	NH2-PEG4-CH2CH2COOH is a degradable (cleavable) 4-unit PEG-like ADC linker, for the synthesis of antibody-conjugated drugs (ADCS). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker and can be used in the synthesis of PROTAC.
Target	Cleavable PEGs
in vitro study	ADCs are combined of an antibody to which is attached an ADC cytoxin through an ADC linker. PROTACs contains two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intrinsic ubiquitin-proteasome system to selective grade target proteins.

Last Update：2024-04-09 20:49:11

α-amine-ω-propionic acid tetraethylene glycol

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